Systems Biology University of Freiburg
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Christian Tönsing

Faculty of Mathmatics and Physics
Insitute of Physics
University of Freiburg
 
Hermann-Herder-Str. 3
79104 Freiburg i.Br.
Germany

christian.toensing -at- fdm.uni-freiburg.de



phone: +49 761 203 7633

office: Physics high-rise, room 207



 
Research interests
- Parameter estimation and optimal experimental design methods for biochemical reaction network models
- Sloppiness in ordinary differential equation (ODE) models
- Mathematical modelling of erythropoiesis: SBEpo
- Analysis of reverse phase protein lysate microarray (RPPA) data
- Hypoxia in breast cancer
- Profile likelihood analyses
- Clustering analysis of high dimensional data
- Infectious disease models (ODEs)
- Dynamical modelling frameworks (d2d)

Publications

Tönsing C., Timmer J., Kreutz C.
Profile likelihood based analyses of infectious disease models
to appear in Statistical Methods in Medical Research (2017)
Influenza data, model & scripts
Zika Virus data, models & scripts

A. Raue, B. Steiert, M. Schelker, C. Kreutz, T. Maiwald, H. Hass, J. Vanlier, C. Tönsing, L. Adlung, R. Engesser, W. Mader, T. Heinemann, J. Hasenauer, M. Schilling, T. Höfer, E. Klipp, F. Theis, U. Klingmüller, B. Schöberl, J. Timmer
Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems
Bioinformatics. doi:10.1093/bioinformatics/btv405 (2015)

Tönsing C., Timmer J., Kreutz C.
Cause and cure of sloppiness in ordinary differential equation models
Phys. Rev. E 90, 023303 (2014)

Reviewer for:
- Journal of the American Statistical Association
- Bioinformatics

Conferences
09/2017 Talk Cause and Cure of Sloppiness in Ordinary Differential Equation Models
ODE Modelling in Systems Biology, FRIAS Junioir Researcher Conference, 2017 Freiburg, (GER)
03/2017 Talk Cause and Cure of Sloppiness in Ordinary Differential Equation Models
Frühjahrstagung Deutsche Physikalische Gesellschaft (DPG) 2017 Dresden, (GER)
04/2016 Poster Cause and Cure of Sloppiness in Ordinary Differential Equation Models
6th Conference on Systems Biology of Mammalian Cells (SBMC), Munich (GER)
07/2015 Lightning Talk & Poster
Cause and Cure of Sloppiness in Ordinary Differential Equation Models
International Conference on Systems Biology of Human Disease 2015 (SBHD), Heildelberg (GER)
06/2015 Talk & Poster Cause and Cure of Sloppiness in Ordinary Differential Equation Models
[BC]^2 Basel Compitational Biology Conference 2015, Basel (CH)
05/2014 Poster Cause and Cure of Sloppiness in Ordinary Differential Equation Models
5th Conference on Systems Biology of Mammalian Cells (SBMC), Berlin (GER)
03/2014 Talk & Poster On the Cause and Cure of Sloppiness in Ordinary Differential Equation Models
Advanced Lecture Course on Systems Biology 2014, Innsbruck (AT)
07/2013 Poster Using experimental design methods to reduce the Sloppiness of an ODE Model
International Conference on Systems Biology (ICSB) 2013, Copenhagen (DK)
07/2012 Poster Experimental design for parameter estimation: Are ODE models 'sloppy'?
4th Conference on Systems Biology of Mammalian Cells (SBMC), Leipzig (GER)
03/2012 Poster Experimental design for parameter estimation: Are ODE models 'sloppy'?
Helmholtz Alliance on Systems Biology Spring School 2012, Seeon (GER)
01/2012 Poster Experimental design for parameter estimation: Are ODE models 'sloppy'?
International Symposium on Quantitative Biology and Cytokine Signaling, Engelberg (CH)
10/2011 Attendance
06/2010
Attendance 3th Conference on Systems Biology of Mammalian Cells (SBMC), Freiburg (GER)




Curriculum Vitae:
11/2013 -
PhD student in the group of Prof. Dr. Jens Timmer
05/2013 - 10/2013 'Wissenschaftlicher Mitarbeiter' in the group of Prof. Dr. Jens Timmer
10/2011 - 04/2013 Diploma thesis in physics in the group of Prof. Dr. Jens Timmer
08/2009 - 04/2010
10/2008 - 04/2013
Graduate student in physics at Albert-Ludwigs-Universität Freiburg
10/2006 - 10/2008 Undergraduate Student in physics at Albert-Ludwigs-Universität Freiburg
08/2005 - 04/2006 Civilian service at the German Red Cross (DRK), Bad Lippspringe
06/2005 Abitur at Gymnasium Theodorianum, Paderborn
01/1986 Born in Itzheoe



Teaching

SS 2016 Tutor Übungen zu Experimentalphysik 2
WS 2015/16 Tutor Übungen zu Analysis für Physiker
SS 2015 Organisation und Tutor der Übungen zu "Statistik und Numerik"
WS 2014/15 Tutor Übungen zu Theoretische Physik 1
SS 2014 Tutor Übungen zu Experimentalphysik 2
WS 2013/14 Tutor Übungen zu Theoretische Physik 3: Elektrodynamik und SRT
WS 2012/13 Organisation und Tutor der Übungen zu "Mathematik für Bioinformatik und Systembiologie"
Summer 2012 Tutor Physikalisches Anfängerpraktikum
Spring 2012 Tutor Physikalisches Anfängerpraktikum
WS 2011/12 Tutor Übungen zur Experimentalphysik 1
Oktober 2011 Tutor Mathematik Vorkurs für Physiker
Spring 2011 Tutor Physikalisches Anfängerpraktikum
SS 2010 Tutor Physikalisches Anfängerpraktikum
SS 2009 Tutor Physikalisches Anfängerpraktikum



Links:


Group of Dr. Clemens Kreutz: Statistics in Biomedical Research Group

Group of Prof. Dr. Jens Timmer: Data Analysis and Modeling of Dynamic Processes in the Life Sciences



D2D - data 2 dynamics software