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Research
interests
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- Parameter estimation
and optimal experimental design methods for
biochemical reaction network models
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- Sloppiness in ordinary differential
equation (ODE) models
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- Mathematical modelling of
erythropoiesis
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- Analysis of reverse phase protein lysate
microarray (RPPA) data
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- Hypoxia in breast
cancer
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| - Profile likelihood analyses |
| - Infectious disease models (ODEs) |
| - Dynamical modelling frameworks (d2d)
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- Optimal paths in high
dimensional likelihood landscapes
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Publications
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Adlung L.*, Stapor P.*,
Tönsing C.*,
Schmiester L.,
Schwarzmüller L.E., Wang
D., Timmer J., Klingmüller
U., Hasenauer J., Schilling
M.
Cell-to-cell
variability in JAK2/STAT5
pathway components and
cytoplasmic volumes define
survival threshold in
erythroid progenitor cells
Cell Reports 36, 109507 (2021)
doi: 10.1016/j.celrep.2021.109507
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Tönsing
C.*, Timmer J., Kreutz C.
Optimal
Paths Between Parameter Estimates
in Nonlinear ODE Systems Using the
Nudged Elastic Band Method
Frontiers in Physics, 7:149, (2019)
doi: 10.3389/fphy.2019.00149
NEB
code (d2d)
Swameye
NEB example (d2d)
|
|
Bernhardt S.*, Tönsing
C.*, Mitra D., Erdem N.,
Müller-Decker K., Korf U., Kreutz C., Timmer
J., Wiemann S.
Functional
proteomics of breast cancer metabolism
identifies GLUL as responder during
hypoxic adaptation
Journal of Proteome Research, 18 (3),
1352-1362. (2019)
doi: 10.1021/acs.jproteome.8b00944 |
|
Tönsing
C.*, Timmer J., Kreutz C.
Profile
likelihood-based analyses of infectious
disease models (pdf)
Statistical Methods in Medical Research,
27(7), 1979–1998. (2018)
doi: 10.1177/0962280217746444
Influenza
data, model & scripts
Zika
Virus data, models & scripts |
|
A.
Raue, B. Steiert, M. Schelker, C. Kreutz, T.
Maiwald, H. Hass, J. Vanlier, C.
Tönsing, L. Adlung, R. Engesser,
W. Mader, T. Heinemann, J. Hasenauer, M.
Schilling, T. Höfer, E. Klipp, F. Theis, U.
Klingmüller, B. Schöberl, J. Timmer
Data2Dynamics:
a modeling environment tailored to
parameter estimation in dynamical systems
Bioinformatics. btv405 (2015)
doi:10.1093/bioinformatics/btv405 |
|
Tönsing
C.*, Timmer J., Kreutz C.
Cause
and cure of sloppiness in ordinary
differential equation models
Phys. Rev. E 90,
023303 (2014)
doi: 10.1103/PhysRevE.90.023303 |
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* main authors
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| Reviewer
for: |
|
| - Royal Society Open Science |
| - Journal of the American Statistical
Association |
- Bioinformatics
|
- BMC Bioinformatics
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Conferences
|
| 11/2019 |
Poster
|
Optimal path between parameter estimates in
nonlinear ODE systems
INCOME2019
Conference: Integrative pathway modeling in
systems biology and systems medicine, Berlin (GER) |
| 05/2019 |
Poster |
Optimal paths between parameter estimates in
nonlinear ODE systems
International
Conference on Systems Biology of Human Disease
2019 (SBHD), Berlin (GER) |
| 04/2019 |
Poster |
Optimal paths between parameter estimates in
nonlinear ODE systems
Dutch
Bioinformatics & Systems Biology Conference
2019, Lunteren (NL) |
| 10/2018 |
Poster |
Optimal path between parameter estimates in
nonlinear ODE systems
INCOME2018
Conference: Integrative pathway modeling in
systems biology and systems medicine, Bernried
(GER) |
| 07/2018 |
Poster |
Optimal path between parameter estimates in
nonlinear ODE systems
7th
Conference on Systems biology of Mammalian Cells
(SBMC), Bremen (GER) |
| 03/2018 |
Talk |
Profile likelihood based analyses of infectious
disease models
Frühjahrstagung
Deutsche Physikalische Gesellschaft (DPG) 2018
Berlin, (GER) |
| 09/2017 |
Invited Talk |
Cause and Cure of Sloppiness in Ordinary
Differential Equation Models
ODE
Modelling in Systems Biology, FRIAS Junior
Researcher Conference, 2017 Freiburg, (GER) |
| 03/2017 |
Talk |
Cause and Cure of Sloppiness in Ordinary
Differential Equation Models
Frühjahrstagung
Deutsche Physikalische Gesellschaft (DPG) 2017
Dresden, (GER) |
| 04/2016 |
Poster |
Cause and Cure of Sloppiness in Ordinary
Differential Equation Models
6th
Conference on Systems Biology of Mammalian Cells
(SBMC), Munich (GER) |
| 07/2015 |
Lightning Talk & Poster
|
Cause and Cure of
Sloppiness in Ordinary Differential Equation Models
International
Conference on Systems Biology of Human Disease
2015 (SBHD), Heidelberg (GER) |
| 06/2015 |
Talk & Poster |
Cause and Cure of Sloppiness in Ordinary
Differential Equation Models
[BC]^2
Basel Compitational Biology Conference 2015, Basel
(CH) |
| 05/2014 |
Poster |
Cause and Cure of Sloppiness in Ordinary
Differential Equation Models
5th
Conference on Systems Biology of Mammalian Cells
(SBMC), Berlin (GER) |
| 03/2014 |
Talk & Poster |
On the Cause and Cure of Sloppiness
in Ordinary Differential Equation Models
Advanced
Lecture Course on Systems Biology 2014, Innsbruck
(AT) |
| 07/2013 |
Poster |
Using experimental design methods to
reduce the Sloppiness of an ODE Model
International
Conference on Systems Biology (ICSB) 2013,
Copenhagen (DK)
|
| 07/2012 |
Poster |
Experimental design for parameter
estimation: Are ODE models 'sloppy'?
4th
Conference on Systems Biology of Mammalian Cells
(SBMC), Leipzig (GER)
|
| 03/2012 |
Poster |
Experimental design for parameter
estimation: Are ODE models 'sloppy'?
Helmholtz Alliance on Systems Biology Spring
School 2012, Seeon (GER)
|
| 01/2012 |
Poster |
Experimental design for parameter
estimation: Are ODE models 'sloppy'?
International
Symposium on Quantitative Biology and Cytokine
Signaling, Engelberg (CH) |
| 10/2011 |
Attendance |
LifeNet
Conference on "Integrative 'Omics' Approaches to
Disease Mechanisms - from emerging technologies to
new perspectives", Munzingen (GER)
|
06/2010
|
Attendance |
3th
Conference on Systems Biology of Mammalian Cells
(SBMC), Freiburg (GER) |
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