Dr. Daniel Kaschek

Address Institute of Physics
Hermann-Herder-Str. 3
79104 Freiburg

Office: Institute of Physics, high-rise building, 210
Phone: +49 761 203 8531
Email: daniel.kaschek 'at' physik.uni-freiburg.de

Leader of the sub-group "Physical Methods in Systems Biology".

Method development:
Parameter estimation in differential equation models
Uncertainty analysis by the profile-likelihood method
Statistical properties of cost functionals and their application in input estimation
Lie symmetries and structural parameter identifiability
Differential geometry of least-squares estimation problems

Applied research:
The impact of therapeutic antibodies on the MAPK/PI3K pathways in HER2+/- breast cancer cell lines
Effects of toxic compounds on NFkB and NRF2 signaling
The impact of cholestatic drugs on bile acid transport

List of R/Python packages I am working on:
blotIt2 (alignment of immunoblot and protein array data by mixed effects models, last update: Dec. 9, 2016)
calibrator (calibration of protein array and luminex data, last update: Sep. 18, 2013)
cOde (Interface between C and the deSolve package for R, hosted on GitHub)
dMod (Framework for dynamic modeling and parameter estimation in R, hosted on GitHub)
Lie symmetry detection (Direct search algorithm for the detection of Lie point symmetries, Dec. 14, 2015, Author: Benjamin Merkt)


date: 02.11.2016