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| Research interests: |
| development and analyses of ODE models of signal transduction pathways and gene-regulatory network under normal and abnormal conditions |
| - effects of mutations and prediction of effective target points |
| - impact of individual processes on signalling characteristics |
| - impact of feedbacks |
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| Projects involved in: |
| DNp73-IGF1R signalling-based systems model for the prediction of metastasis probability and therapy responses in malignant melanoma |
| The project is in collaboration with the Institute of Experimental Gene Therapy and Cancer Research at Rostock University Medical Center. |
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| Publications: |
| Baum, K., Politi, A. Z., Kofahl, B., Steuer, R., and Wolf, J. (2016) |
| Feedback, mass conservation and reaction kinetics impact the robustness of cellular oscillations |
| PLoS Computational Biology 12, e1005298. |
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| Benary, U., Kofahl, B., Hecht, A., and Wolf, J. (2015) |
| Mathematical Modelling Suggests Differential Impact of β-TrCP Paralogues on Wnt/β-Catenin Signalling Dynamics |
| FEBS Journal 282, 1080-1096. |
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| Mothes, J., Busse, D., Kofahl, B., and Wolf, J. (2015) |
| Sources of dynamic variability in NF-κB signal transduction: a mechanistic model |
| Bioessays 37, 452-462. |
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| Yılmaz, Z.B., Kofahl, B.*, Beaudette, P.*, Baum, K., Weih, F., Wolf, J., Dittmar, G., and Scheidereit, C. (2014) |
| Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis |
| Cell Reports 9, 1756–1769. (*: equal contribution) |
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| Benary, U.*, Kofahl, B.*, Hecht, A., and Wolf, J. (2013) |
| Modeling Wnt/β-catenin target gene expression in APC and Wnt gradients under wild type and mutant conditions |
| Frontiers in Physiology 4:21. (*: equal contribution) |
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| Kofahl, B. and Wolf J. (2010) |
| Mathematical modelling of Wnt/β-catenin signalling |
| Biochem Soc Trans 38, 1281-1285. |
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| Luo, W., Peterson, A., Garcia, B. A., Coombs, G., Kofahl, B., Heinrich, R., Shabanowitz, J., Hunt, D. F., Yost, H. J., and Virshup, D. M. (2007) |
| Protein phosphatase 1 regulates assembly and function of the β-catenin degradation complex |
| The EMBO Journal 26, 1511–1521. |
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| Schaber, J., Kofahl, B., Kowald, A. and Klipp, E. (2006) |
| A modelling approach to quantify dynamic crosstalk between the pheromone and the starvation pathway in baker's yeast. |
| FEBS Journal 273, 3520-3533. |
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| Nordlander, B., Klipp, E., Kofahl, B. and Hohmann, S. (2005) |
| Modelling signal pathways – a yeast approach |
| In: Alberghina, L. and Westerhoff, H. V. (Eds.): Systems Biology: Definitions and Perspectives. Springer, Heidelberg 277-302. |
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| Klipp, E., Nordlander, B., Kofahl, B., and Hohmann, S. (2004) |
| Shutting the MAP off – and on again? |
| Current Genomics 5, 637-647. |
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| Kofahl, B. and Klipp, E. (2004) |
| Modelling the dynamics of the yeast pheromone pathway |
| Yeast 21, 831-850. |
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