Systems Biology University of Freiburg
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Bente Kofahl

Bente Kofahl

Institute of Physics
University of Freiburg
Physics high-rise, room 207
Hermann-Herder-Str. 3
79104 Freiburg i.Br.
bente.kofahl -at-
phone: +49 761 203 7633



Research interests:
development and analyses of ODE models of signal transduction pathways and gene-regulatory network under normal and abnormal conditions
- effects of mutations and prediction of effective target points
- impact of individual processes on signalling characteristics
- impact of feedbacks

Projects involved in:
DNp73-IGF1R signalling-based systems model for the prediction of metastasis probability and therapy responses in malignant melanoma
The project is in collaboration with the Institute of Experimental Gene Therapy and Cancer Research at Rostock University Medical Center.

Baum, K., Politi, A. Z., Kofahl, B., Steuer, R., and Wolf, J. (2016)
Feedback, mass conservation and reaction kinetics impact the robustness of cellular oscillations
PLoS Computational Biology 12, e1005298.
Benary, U., Kofahl, B., Hecht, A., and Wolf, J. (2015)
Mathematical Modelling Suggests Differential Impact of β-TrCP Paralogues on Wnt/β-Catenin Signalling Dynamics
FEBS Journal 282, 1080-1096.
Mothes, J., Busse, D., Kofahl, B., and Wolf, J. (2015)
Sources of dynamic variability in NF-κB signal transduction: a mechanistic model
Bioessays 37, 452-462.
Yılmaz, Z.B., Kofahl, B.*, Beaudette, P.*, Baum, K., Weih, F., Wolf, J., Dittmar, G., and Scheidereit, C. (2014)
Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis
Cell Reports 9, 1756–1769. (*: equal contribution)
Benary, U.*, Kofahl, B.*, Hecht, A., and Wolf, J. (2013)
Modeling Wnt/β-catenin target gene expression in APC and Wnt gradients under wild type and mutant conditions
Frontiers in Physiology 4:21. (*: equal contribution)
Kofahl, B. and Wolf J. (2010)
Mathematical modelling of Wnt/β-catenin signalling
Biochem Soc Trans 38, 1281-1285.
Luo, W., Peterson, A., Garcia, B. A., Coombs, G., Kofahl, B., Heinrich, R., Shabanowitz, J., Hunt, D. F., Yost, H. J., and Virshup, D. M. (2007)
Protein phosphatase 1 regulates assembly and function of the β-catenin degradation complex
The EMBO Journal 26, 1511–1521.
Schaber, J., Kofahl, B., Kowald, A. and Klipp, E. (2006)
A modelling approach to quantify dynamic crosstalk between the pheromone and the starvation pathway in baker's yeast.
FEBS Journal 273, 3520-3533.
Nordlander, B., Klipp, E., Kofahl, B. and Hohmann, S. (2005)
Modelling signal pathways – a yeast approach
In: Alberghina, L. and Westerhoff, H. V. (Eds.): Systems Biology: Definitions and Perspectives. Springer, Heidelberg 277-302.
Klipp, E., Nordlander, B., Kofahl, B., and Hohmann, S. (2004)
Shutting the MAP off – and on again?
Current Genomics 5, 637-647.
Kofahl, B. and Klipp, E. (2004)
Modelling the dynamics of the yeast pheromone pathway
Yeast 21, 831-850.

Curriculum Vitae:
since 2017 PostDoc in Prof. Dr. Jens Timmer's group "Data Analysis and Modeling of Dynamic Processes in the Life Sciences" at University of Freiburg
2011 - 2017 PostDoc in Dr. Jana Wolf's group "Mathematical Modelling of Cellular Processes" at Max Delbrück Centre for Molecular Medicine (MDC), Berlin
2005 - 2011 PhD student in the groups of "Theoretical Biophysics" at Humboldt-University Berlin, "Mathematical Modelling of Cellular Processes" at MDC and "Data Analysis and Modeling of Dynamic Processes in the Life Sciences"
2004 Diploma thesis in Biophysics at Humboldt-University Berlin
“Mathematical Modelling of Signal Transduction Pathways in Baker’s Yeast”