Local estimate of the fraction of significant p-values
The approach has been developed for tiling arrays.
The approach can be applied if p-values from statistical tests are available in a spatial order (e.g. along the genome)
The GSRI estimates the fraction of significantly regulated features.
A smoothing window is applied in combination (similar to GSRI).
It enables significance statements whether at a certain position a significant fraction of p-values deviate from the uniform distribution.
The outcome can be used to rank genomic regions, i.e. for finding regions of interest.
In contrast to other similar approaches, no reference gene set which is NOT regulated (e.g. “all genes”) is required.
The most prominent similar approach is GSEA (gene set enrichment analysis)